How often should you change the substrate of a non bioactive enclosure
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I don’t know how often you SHOULD do it, but I do it seldom in my enclosures because I use aspen, which is very easy to spot clean. Still, every year or so I feel I should change it out completely. And when I do, I feel like I’m throwing away mostly clean substrate. Not a clear answer, but I hope it helps. 
Note: I keep relatively tidy species of snakes: corns, kings, and rosy boas. There are species that like to smear everything with poop und urates. The mileage of those snakes’ keepers may vary!
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For a crested gecko? As long as you are doing regular spot cleaning, once every 3 months should be sufficient.
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I don’t do anything but bio for Cresties.
But seen people clean ever day to ever other day, and always clean poop out when you see it. Dont leave.
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For a crestie, as long as you are spot cleaning all of the poop you can wait it out a bit. 3 months as Logar said isn’t too bad.
However, if you notice an odor, any type of fungus or bacteria growth or odd bugs crawling around (like ants) definitely change it out sooner than later!
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